当前位置: 首页 > >

冠状动脉微栓塞动物模型磁共振成像研究及其进展_论文

发布时间:

磁共振成像 2018年第9卷第4期 Chin J Magn Reson Imaging, 2018, Vol 9, No 4 综 述 | Reviews 冠状动脉微栓塞动物模型磁共振成像研究及其进展 赵士海1,2,金航1,2* 基金项目: [摘要]? 冠状动脉微栓塞(coronary microembolization,CME)常见于急性冠脉综 国 家 自 然 科 学 基 金 项 目 ( 编 号 : 合症和经皮冠状动脉治疗术(percutaneous coronary intervention,PCI)过程中,危 81201070) 害很大。*年来,国内接受PCI的患者数量大幅增长,由此引起的CME病变也 越来越常见。与其他影像学检查方法相比,MRI具有无创、无电离辐射、软组 作者单位: 织分辨率高等优势,并可“一站式”检查获取心脏解剖和功能信息,常被用于 1.复旦大学附属中山医院放射科,上 评估微栓塞后心肌功能和灌注异常、进行心肌活性成像,在冠状动脉微栓塞病 海市影像医学研究所,上海 200032 变的研究中起着重要作用。CME动物模型常被用于深入研究微栓塞病变的病理 2.复旦大学上海医学院影像学系,上 生理改变、心肌损伤机制,本文主要概述MRI在CME动物模型方面的研究及其 海 200032 进展。 [关键词] 冠状动脉微栓塞;磁共振成像;动物模型 通讯作者: 金航,E-mail:hangjin08@163.com Research and progress of magnetic resonance imaging on 收稿日期:2017-11-20 coronary microembolization using animal models 接受日期:2018-01-24 中图分类号:R445.2;R332 文献标识码:A DOI: 10.12015/issn.1674-8034.2018.04.013 ZHAO Shi-hai1,2, JIN Hang1,2* 1Department of Radiology, Zhongshan Hospital, Fudan University and Shanghai Institute of Medical Imaging, Shanghai 200032, China 2Department of Medical Imaging, Shanghai Medical College of Fudan University, Shanghai 200032, China *Corresponding to: Jin H, E-mail:hangjin08@163.com 赵士海, 金航. 冠状动脉微栓塞动物模 型磁共振成像研究及进展. 磁共振成 Received 20 Nov 2017, Accepted 24 Jan 2018 ACKNOWLEDGMENTS This work was part of National Natural Science Foundation of China (No. 81201070). 像, 2018, 9(4): 303-307. Abstract? Coronary microembolization (CME) occurs frequently in acute coronary syndrome and the process of percutaneous coronary intervention (PCI), which is very harmful for patients. In recent years, the number of patients receiving PCI in China has increased significantly, and the coronary microembolization after PCI also becomes more common than ever. Compared with other methods, magnetic resonance imaging (MRI) is a noninvasive method without ionizing radiation and has the advantages of high soft tissue resolution and one-stop inspection with cardiac anatomy and function information. MRI plays an important role in the study on coronary microembolization and can be used to assess myocardial function, perfusion abnormalities and myocardial activity related to coronary microembolization. Animal models of coronary microembolization were commonly used in-depth study on pathophysiology of CME and mechanism of relevant myocardial injury. This review focused on research and progress in MRI on coronary microembolization of animal models. Key words? Coronary microembolization; Magnetic resonance imaging; Animal models 1 冠状动脉



友情链接: